Vaccine Delivery System is used to promote uptake of the vaccines with the help of absorption enhancers in vaccine formulations. Oral Vaccines are notable developments in vaccine delivery technologies.
• Absorption Enhancers
Absorption Enhancement is the technology aimed at enabling non-injection delivery of poorly membrane permeable compounds.
An Absorption Enhancer is an agent whose function is to increase absorption by enhancing membrane permeation, rather than increasing solubility, so such agents are sometimes more specifically termed as permeation enhancers.
• Liposomal Delivery System
Liposomes are composed of phospholipid bilayers capable of entrapping hydrophilic moieties in the aqueous compartment and hydrophobic moieties in the lipid bilayer.
As vaccine adjuvants these system exert immunomodulatory effects by virtue of their particulate nature and their ability to bind with cell surface lipid receptors such as CD1a.
• Oral Immunization
Oral polio vaccine (OPV) is a live attenuated vaccine, produced by the passage of the virus through non-human cells at a sub-physiological temperature, which produces spontaneous in the viral genome. OPV is usually provided in vials containing 10-20 doses of vaccine.
• Controlled Release Micro Particles for Vaccine Delivery
PLGA (polylactide co-glycolic acid) is used as a Biodegradable Micro particle for Vaccine Delivery due to the abundance of data and information on it’s properties, uses, and role in ongoing studies.
A particularly interesting area is the use of biodegradable microparticles to deliver DNA vaccines.
- Polymers in solid particulate vaccine delivery
- Liposomal delivery systems
- Emulsion delivery systems
- Polymeric nanoparticle delivery systems
- Micellar delivery systems
- Dendrimer-based delivery systems